Barriers and enablers to the implementation of infection prevention and control guidance in a Ugandan healthcare facility – a theory-informed qualitative study to guide intervention design
DOI:
https://doi.org/10.3396/ijic.v21.23768Keywords:
infection prevention and control guidance, behaviour change, qualitative, low-resource settingsAbstract
Implementing Infection Prevention and Control (IPC) guidance is crucial for reducing healthcare-associated infection (HAI) rates. However, achieving behavioural and organisational change is necessary for successful implementation. To understand these changes, it is important to identify the barriers and facilitators to IPC implementation, supported by theoretical analysis.
This paper presents the second stage of a study conducted in Uganda, aiming to analyse barriers and enablers to IPC guideline implementation and provide preliminary recommendations for intervention design. Interviews with frontline healthcare workers were conducted, and qualitative content analysis helped identify specific barriers and enablers. The Theoretical Domains Framework (TDF) was used to categorise and map these factors to the BCW/COM-B model, enabling the identification of intervention functions supporting IPC implementation.
The findings highlighted various important factors influencing IPC implementation, including social influences, environmental context and resources, knowledge, skills, professional role and identity, behavioural regulation, memory, attention and decision processes, goals, beliefs about capabilities, beliefs about consequences, intentions, emotion, and reinforcement. All components of the COM-B model (Capability, Opportunity, Motivation) were deemed significant in IPC implementation. Key intervention functions such as enablement, environmental restructuring, training and education, persuasion, and incentivization were identified as potentially useful for designing interventions to improve IPC implementation.
In conclusion, the analysis emphasized the interconnectedness and importance of capability, opportunity, and motivation in adopting IPC guidance in such contexts. The study offers recommendations for future interventions, including education and training programs, leveraging memory and attention, addressing beliefs about consequences, and improving social influences and support systems. These insights can guide the development of effective strategies to enhance IPC implementation.
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References
1. WHO. Global report on infection prevention and control [Internet]. Geneva; 2022, p. 148. Available from: https://www.who.int/publications-detail-redirect/9789240051164 [cited 10 July 2023].
2. WHO. Guidelines on core components of infection prevention and control programmes at the national and acute health care facility level [Internet]. 2016. Available from: http://apps.who.int/bookorders [cited 15 January 2022].
3. Fischer F, Lange K, Klose K, Greiner W, Kraemer A. Barriers and strategies in guideline implementation – a scoping review. Healthcare 2016; 4(3): 36. doi: 10.3390/healthcare4030036
4. Moore L, Britten N, Lydahl D, Naldemirci Ö, Elam M, Wolf A. Barriers and facilitators to the implementation of person-centred care in different healthcare contexts. Scand J Caring Sci 2017; 31(4): 662–73. doi: 10.1111/scs.12376
5. Michie S, Atkins L, West R. The Behaviour Change Wheel: A Guide to Designing interventions. London: Silverback Publishing; 2014. Available from: https://www.behaviourchangewheel.com/ [cited 15 January 2024].
6. Francis JJ, O’Connor D, Curran J. Theories of behaviour change synthesised into a set of theoretical groupings: introducing a thematic series on the theoretical domains framework. Implement Sci 2012; 7(1): 35. doi: 10.1186/1748-5908-7-35
7. De Leo A, Bayes S, Bloxsome D, Butt J. Exploring the usability of the COM-B model and Theoretical Domains Framework (TDF) to define the helpers of and hindrances to evidence-based practice in midwifery. Implement Sci Commun 2021; 2(1): 7. doi: 10.1186/s43058-020-00100-x
8. Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci 2011; 6(1): 42. doi: 10.1186/1748-5908-6-42
9. Mayne, J. The COM-B Theory of Change Model (V3). Res Gate 2018; 4: 1–12.
10. Greene C, Wilson J. The use of behaviour change theory for infection prevention and control practices in healthcare settings: a scoping review. J Infect Prev 2022; 23(3): 108–17. doi: 10.1177/17571774211066779
11. Kalule A. Striving: a grounded theory of healthcare workers’ struggles in implementing infection prevention and control guidance in Uganda [Internet]. Glasgow: Glasgow Caledonian University; 2023. Available from: https://researchonline.gcu.ac.uk/en/studentTheses/striving-a-grounded-theory-of-healthcare-workers-struggles-in-imp [cited 15 January 2024].
12. Charmaz K. Constructing grounded theory. 2nd ed. London: SAGE Publications; 2014.
13. Kalule AO, Currie K, Price L. Striving for improved infection prevention and control practice: a grounded theory of healthcare workers’ struggles in implementing infection prevention and control guidance in Uganda. Qual Health Res 2024; 34(13): 1303–14. doi: 10.1177/10497323241242660
14. Ministry of Health. Uganda national infection prevention and control guidelines. Kampala: Government of Uganda; 2013, p. 109. Available from: https://library.health.go.ug/monitoring-and-evaluation/quality-assurance-improvement/uganda-national-infection-prevention-and [cited 15 January 2024].
15. Michie S, Richardson M, Johnston M, Abraham C, Francis J, Hardeman W, et al. The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. Ann Behav Med Publ Soc Behav Med 2013; 46(1): 81–95. doi: 10.1007/s12160-013-9486-6
16. Baker R, Camosso-Stefinovic J, Gillies C, Shaw B, Cheater F, Flottorp S, et al. Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database Syst Rev Online 2010; 3: CD005470. doi: 10.1002/14651858.CD005470.pub2
17. Herbeć A, Chimhini G, Rosenberg-Pacareu J, Sithole K, Rickli F, Chimhuya S, et al. Barriers and facilitators to infection prevention and control in a neonatal unit in Zimbabwe – a theory-driven qualitative study to inform design of a behaviour change intervention. J Hosp Infect 2020; 106(4): 804–11. doi: 10.1016/j.jhin.2020.09.020
18. Manchanda V, Suman U, Singh N. Implementing infection prevention and control programs when resources are limited. Curr Treat Options Infect Dis 2018; 10(1): 28–39. doi: 10.1007/s40506-018-0142-3
19. Tu R, Elling H, Behnke N, Tseka JM, Kafanikhale H, Mofolo I, et al. A qualitative study of barriers and facilitators to adequate environmental health conditions and infection control for healthcare workers in Malawi. H2Open J 2022; 5(1): 11–25. doi: 10.2166/h2oj.2022.139
20. Houghton C, Meskell P, Delaney H, Smalle M, Glenton C, Booth A, et al. Barriers and facilitators to healthcare workers’ adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis. Cochrane Database Syst Rev 2020; 4(4): CD013582. doi: 10.1002/14651858.CD013582
21. McAteer J, Stone S, Fuller C, Michie S. Using psychological theory to understand the challenges facing staff delivering a ward-led intervention to increase hand hygiene behavior: a qualitative study. Am J Infect Control 2014; 42(5): 495–9. doi: 10.1016/j.ajic.2013.12.022
22. Yang Q, Wang X, Zhou Q, Tan L, Zhang X, Lai X. Healthcare workers’ behaviors on infection prevention and control and their determinants during the COVID-19 pandemic: a cross-sectional study based on the theoretical domains framework in Wuhan, China. Arch Public Health 2021; 79(1): 118. doi: 10.1186/s13690-021-00641-0
23. Ider BE, Adams J, Morton A, Whitby M, Clements A. Perceptions of healthcare professionals regarding the main challenges and barriers to effective hospital infection control in Mongolia: a qualitative study. BMC Infect Dis 2012; 12(1): 170. doi: 10.1186/1471-2334-12-170
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